Banca de DEFESA: RAMON WEYLER DUARTE LEOPOLDINO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : RAMON WEYLER DUARTE LEOPOLDINO
DATA : 20/02/2018
HORA: 15:00
LOCAL: SALA 2 DO PPGCF
TÍTULO:

DRUG RELATED PROBLEMS AND FACTORS ASSOCIATED WITH THEIR OCCURRENCE IN NEONATAL INTENSIVE CARE

PALAVRAS-CHAVES:

Drug therapy, Drug related problems, Neonate, Intensive care unit.

PÁGINAS: 79
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Introduction: Drug Related Problem (DRP) is any event related to pharmacotherapy that actually or potentially interferes with the desirable clinical outcome. DRPs are very common in intensive care, however, little is known about DRPs in Neonatal Intensive Care Units (NICU). Objective: To characterize DRPs in neonatal intensive care according to type, cause and pharmaceutical conducts, identifying factors and medications associated with their occurrence. Methods: A prospective observational study was conducted in the NICU of a teaching hospital in Brazil from January 2014 to November 2016, based on the records of the clinical pharmacy service, excluding neonates with length of stay< 24 hours and with no prescribed drugs. DRPs were classified according to the Pharmaceutical Care Network Europe system and assessed for safety-relevance. Logistic regression analysis was applied to identify factors and drugs associated with DRPs. Results: Six hundred neonates were included in the study with mean gestational age of 31.9±4.1 weeks and birth weight of 1,779.4±885,3 g. The incidence of DRPs was 67.7 cases/1,000 patient-days (95%CI 62.0 – 73.4). Sub-optimal effect (52.8%) and inappropriate dose choice (39.75%) were the most common problem and cause, respectively. Most of the pharmaceutical interventions were performed at the prescription level, with over 90% being accepted by the NICU team. Number of medications (OR 1.19; 95%CI 1.09 – 1.30), number of clinical problems (OR 1.17; 95%CI 1.01 – 1.37), length of stay (OR 1.05; 95%CI 1.02 – 1.07) and vaginal delivery (OR 1.61; IC95% 1.04-2.50) were associated with DRPs. Medicines with increased risk for DRP were alprostadil, amikacin, aminophylline, amphotericin B, ciprofloxacin, fluconazole, gentamicin, meropenem, phenobarbital and vancomycin. These drugs represent only one-third of all prescribed drugs. Conclusions: DRPs are very common in NICU, predominating problems of sub-optimal treatment, mainly due to inappropriate dose choice.

MEMBROS DA BANCA:
Presidente - 1048067 - ANTONIO MANUEL GOUVEIA DE OLIVEIRA
Externo à Instituição - MARCIO GALVÃO GUIMARÃES DE OLIVEIRA - UFBA
Externo ao Programa - 3168491 - NILBA LIMA DE SOUZA
Externo ao Programa - 1052612 - RODRIGO DOS SANTOS DINIZ