Banca de QUALIFICAÇÃO: IZOLA MORAIS DE MEDEIROS RAMALHO
Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.DISCENTE : IZOLA MORAIS DE MEDEIROS RAMALHO
DATA : 31/08/2017
HORA: 09:00
LOCAL: SALA 2 DO PPgCF
TÍTULO:
Chrysin loaded microemulsion: Preparation, characterization and in vivo anti-inflammatory and antinociceptive activity
PALAVRAS-CHAVES:
Chrysin, microemulsion, drug delivery systems, flavonoid, inflammation, mechanical hyperalgesia.
PÁGINAS: 101
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:
Microemulsion containing Chrysin was developed and characterized for use as anti-inflammatory and antinociceptive formulation. The transparent formulation was developed through a ternary phase diagram. Chrysin-loaded microemulsion (CS-ME) was composed of 40% Labrasol® as surfactant, 5% of isopropyl myristate as the oil phase (O) and 55% of water as aqueous phase. It was classified as an isotropic oil-in-water (O/W) system within nanosized range (170,7 ± 5,3 nm) and negative zeta potential (-16,1 ± 1,9 mV) confirmed by polarized light microscopy, and dynamic light scattering (DLS) analysis. In vitro studies using static diffusion Franz cells revealed that the release of Chrysin from CS-ME followed the zero-order model. CS-ME oral administration produced a significantly reduction (p < 0.05) in the mechanical hyperalgesia induced by carrageenan when compared with control group. The treatment with CS-ME also showed anti-inflammatory activity by significantly (p < 0.01) decreased tumor necrosis factor alpha (TNF α) paw levels, when compared with control group, and by the significantly (p < 0.05) increased interleukin 10 (IL 10) paw levels, when compared with control groups. Our results suggested that this colloidal nanosystem is a promising agent for the delivery of chrysin, increasing its ability to modulate the inflammatory and nociceptive responses.
MEMBROS DA BANCA:
Presidente - 1714294 - MARCIO FERRARI
Interno - 2374605 - AURIGENA ANTUNES DE ARAUJO
Externo ao Programa - 1753094 - ALCIDES DE OLIVEIRA WANDERLEY NETO