Banca de DEFESA: TAMIRES ROCHA FALCAO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : TAMIRES ROCHA FALCAO
DATA : 03/07/2017
HORA: 14:00
LOCAL: Auditório da Faculdade de Farmácia
TÍTULO:

ATIVIDADE ANTI-INFLAMATÓRIA E ANTINOCICEPTIVA DOS
EXTRATOS BRUTOS E FRAÇÕES DE Eugenia uniflora e Libidibia ferrea IN
VIVO.

PALAVRAS-CHAVES:

Libidibia ferrea, Eugenia uniflora L., antinociceptive, anti-inflammatory activity; Oxidative stress.

PÁGINAS: 123
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

The species Libidibia ferrea, popularly known as pau-ferro is used in traditional medicine
as antibacterial, antiulcerogenic, anti-inflammatory and analgesic. Eugenia uniflora L.,
family Myrtaceae is known as pitanga, popularly used in the treatment of diarrhea,
inflammation, hyperglycemia and hypertension. Considering the importance of medicinal
plants as a source of new drugs for the treatment of several pathologies, the involvement of
the inflammatory process in numerous diseases and the strong indications of
pharmacological activity associated with the presence of bioactive substances present in
these species, a Pre- Clinical study with the objective of evaluating an antiinflammatory
and antinociceptive activity of extracts and witches of Libidibia ferrea and Eugenia
Uniflora L., using carrageenan-induced peritonitis model, hot plate test and acetic acid
induced contortions in Swiss mice species Mus Musculus. From the dried and crushed
vegetable materials, crude extracts and fractions of Eugenia uniflora L. (crude aqueous
extract, aqueous fraction, hexane fraction and ethyl acetate fraction) and of libidibia ferrea
were obtained by general methods of pharmacology, extracted crude extracts With ethanol
20, 40, 60 and 80%, fraction ethyl acetate and aqueous fraction). As chromatographic
analyzes of crude extracts and fractions allowed to separate and identify gallic acid, with
retention time of about 8.7 minutes, and ellagic acid, with retention time of 25.1 minutes,
flavonoids were detected, confirmed with the data In the evaluation of leukocyte migration,
or crude extract fractions of Eugenia uniflora L. and Libidibia ferrea at doses of 50 mg /
kg, 100 and 200 mg / kg reduced the number of inflammatory cells to the site of
inflammation (p <0.001 ) Comparing the groups treated with the positive control group.
The decrease in the cellular influx was accompanied by a decrease in myeloperoxidase
activity, reduction of MDA, and showed protection against a glutathione depletion (p
<0.001). The administration of crude extracts and fractions produced an antinociceptive
response at all doses tested, reducing the significant number of contortions induced by
acetic acid in mice, but showed little significant central analgesic activity, being evaluated
by the hot plate test. The results indicate that these plants have anti-inflammatory and
antinociceptive activities. However, other studies are needed for the elucidation of two
pharmacological, Studies at systemic level and toxicological properties.

MEMBROS DA BANCA:
Presidente - 2374605 - AURIGENA ANTUNES DE ARAUJO
Externo à Instituição - LÊONIA MARIA BATISTA - UFPB
Interno - 1544647 - MATHEUS DE FREITAS FERNANDES PEDROSA