Banca de DEFESA: WALTER FERREIRA DA SILVA JUNIOR

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : WALTER FERREIRA DA SILVA JUNIOR
DATA : 31/05/2017
HORA: 14:00
LOCAL: Auditório da Faculdade de Farmácia
TÍTULO:

DESENVOLVIMENTO DE COMPLEXOS DE INCLUSÃO E DISPERSÕES
SÓLIDAS DA α, β AMIRINA ISOLADA A PARTIR DO Protium heptaphyllum

PALAVRAS-CHAVES:

Amyrin. Solid dispersions. Inclusion Complexes. Anti-inflammatory activity. Physicochemical characterization.

PÁGINAS: 116
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

α, β amyrin (ABAM) is a natural mixture of triterpenes pentacyclis which has various
biological activities, including the anti-inflammatory effect. Are isolated from the
species in the family Burseraceae, in which the species Protium heptaphyllum is
more commonly found in the brazilian Amazon. The inclusion complexes formation
(IC) with the cyclodextrin (CD) and solid dispersions (SD) with hydrophilic polymers
have been applied as alternatives to solve some limitations that new chemical
entities (NCE) have in common, mainly the low solubility in aqueous environments.
So, the objective of this work was to develop IC's the ABAM (ABAM) with β-
cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) and SD with the
hidroximetilcelulose (HPMC), polyethylene glycol (PEG 6000) and
polyvinylpyrrolidone (PVP-30 k). Initially, for the IC, computational theoretical studies
were carried out in which interaction energies were calculated between the βCD and
the ABAM and HPβCD and ABAM. Then, the IC's have been developed with βCD
and HPβCD by mixing physical methods (MF) and kneading (KND). The physical and
chemical characterization of IC's using Fourier transform infrared spectroscopy
(FTIR), scanning electron microscopy (SEM), x-ray diffraction (DRX),
thermogravimetric analysis (TG) and differential scanning calorimetry (DSC). The DS
were obtained through the MF, KND and RE with HPMC, PEG and the PVP. Held the
same characterization techniques that were held for the IC. Beyond characterization
to the DS, the anti-inflammatory activity in vitro and were compared with respect to
their anti-inflammatory activities with the ABAM. The characterization studies showed
the formation of CI between the ABAM and the CD and the formation of solid
dispersions between the ABAM and hydrophilic polymers. In the activity of DS, it was
found that comparing the effect, the same dose of ABAM and same dose of the DS,
the DS as the ABAM had anti-inflammatory activity on macrophages activated by
LPS. Therefore, the DS and CI with ABAM are effective alternatives to modify their
characteristics, improving properties that may interfere in a future therapeutic
formulation.

MEMBROS DA BANCA:
Presidente - 1789788 - ADLEY ANTONINI NEVES DE LIMA
Externo à Instituição - BOLIVAR PONCIANO GOULART DE LIMA DAMASCENO - UEPB
Externo à Instituição - VALDIR F. VEIGA JÚNIOR - UFAM