Banca de QUALIFICAÇÃO: CAROLINNE THAÍSA DE OLIVEIRA FERNANDES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : CAROLINNE THAÍSA DE OLIVEIRA FERNANDES
DATA : 27/04/2017
HORA: 09:30
LOCAL: SALA DE AULA I PPGCF
TÍTULO:

Relationship  of  plasma  vitamin  A  and  vitamin  E  and  mRNA  potential  biomarkers  expressions  with  the  extent  of  coronary  lesion.

PALAVRAS-CHAVES:

Cardiovascular disease; Extension of coronary lesion; Antioxidants; Alpha-tocopherol; and Retinol

PÁGINAS: 29
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Retinol and alpha-tocopherol have been reported to be associated with atherosclerosis. A previously conducted study by our research group suggested that 13 genes could be potential novel biomarkers for the early stage of an acute episode. Here, we aimed to investigate the serum profile of these vitamins and also mRNA expression 13 candidate genes in blood leukocytes of patients with different extent of coronary atherosclerotic lesions but without acute coronary syndrome (ACS). Patients with coronary artery disease (CAD) (n = 177), aged 30 to 74 years and undergoing elective coronary angiography, were selected. The extension of the coronary lesion was assessed by the Friesinger index. Ser m a ha-to o hero an retino ere etermine y HPLC. The genes expression were analyzed by qPCR. Patients in the 10-15 group had increased age when compared to the group with 0-4 lesions (p=0.005). Fasting serum glucose was higher in the 5-9 and 10-15 groups than in the 0-4 group (p<0.001 and p=0.015, respectively). Alpha-tocopherol levels were increasead according to the extent of coronary lesion. AREG, BCL2A1, COX7B, IL18R1 and TREML4 were upregulated in patients of the 10-15 group compared to the 0-4 group (p=0.014; p=0.035; p=0.045, p=0.017 and p=0.022, respectively). Moreover, BCL2A1, BCL2L1 and MYL4 were upregulated in patients of the 5-9 group than 0-4 group (p=0.012; p=0.004 and p=0.011, respectively). On the other hand, ECDHC3 mRNA expression decreases according to the atherosclerotic burden when comparing the 10-15 group with the 0-4 (p=0.039). The alpha-tocopherol involvement with these genes and the extent of coronary lesion open up new possibilities for future studies to understand this vitamin metabolism in coronary heart disease and to evaluate its applicability as biomarkers in case of coronary lesions.

MEMBROS DA BANCA:
Presidente - 346847 - MARIA DAS GRACAS ALMEIDA THORNTON
Externo ao Programa - 4659679 - SANCHA HELENA DE LIMA VALE
Externo ao Programa - 1674709 - VIVIANE SOUZA DO AMARAL