Banca de DEFESA: VICTOR HUGO REZENDE DUARTE

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : VICTOR HUGO REZENDE DUARTE
DATA : 28/04/2017
HORA: 14:00
LOCAL: SALA DE AULA II DO PPGCF
TÍTULO:

POLIMORFISMOS  E  EXPRESSÃO  DE  RNAm  DO  TREML4  EM  LEUCÓCITOS  DE  PACIENTES  COM  DOENÇA  ARTERIAL  CORONARIANA.

PALAVRAS-CHAVES:

Cardiovascular disease; Extension of coronary lesion; TREML4, gene polymorphisms; mRNA expression; Friesinger Index

PÁGINAS: 100
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

The members of the triggering receptor expressed on myeloid cells (TREM) family are associated with the risk and progression of atherosclerosis. We previously reported the upregulation of TREML4 in the early phase of the acute coronary syndrome. Here, we investigated the relationship of TREML4 polymorphisms and mRNA expression in blood leukocytes of patients stratificate according to the extension of coronary artery lesion. Patients with coronary artery disease (CAD) (n = 151), aged 30 to 74 years and undergoing elective coronary angiography, were selected. The extension of coronary lesion was assessed by the Friesinger index. TREML4 rs2803495 (A>G) and rs2803496 (T>C) variants and leukocyte mRNA expression were analyzed by qRT-PCR. TREML4 expression was higher in patients with major coronary artery lesions compared to subjects without or with low and intermediate lesions, (p < 0.05). Subjects carrying rs2803495 G allele (AG/GG genotypes) and rs2803496 C allele (TC/CC genotypes) were more prone to have positive TREML4 mRNA expression (Allele G: OR = 2.4, 95% CI 1.0-5.7, p < 0.05; allele C: OR = 7.8, and 95% CI = 2.9-20.9, p < 0.01, respectively). However, TREML4 polymorphisms were not associated with the extent of coronary lesion. In conclusion, increased TREML4 mRNA expression in blood leukocytes is influenced by gene polymorphisms and it is associated with more severe coronary artery lesions, suggesting its role as potential biomarker to investigate the extent of coronary lesion in CAD patients.

MEMBROS DA BANCA:
Externo à Instituição - LILIA BASILIO DE CALAND - UERN
Externo ao Programa - 2261797 - TIRZAH BRAZ PETTA LAJUS
Presidente - 1804884 - VIVIAN NOGUEIRA SILBIGER