Banca de QUALIFICAÇÃO: IAGO DE SOUZA GOMES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : IAGO DE SOUZA GOMES
DATA : 15/12/2016
HORA: 16:00
LOCAL: SALA DE AULA II DO PPGCF
TÍTULO:

ALBUMINURIA AND LOW BONE MINERAL DENSITY IN PEDIATRIC PATIENTS WITH TYPE 1 DIABETES

PALAVRAS-CHAVES:

Type 1 Diabetes mellitus; diabetic nephropathy; urinary exossomos; WT-1; nephrin and podocin.

PÁGINAS: 67
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Introduction: Diabetic nephropathy (ND) is complication of Type 1 Diabetes
mellitus (T1DM). The loss of podocytes from the renal glomerulus is an early and
key event in the development of ND. The technique to concentrate the urinary
exosomes eliminated in the urine has allowed the quantification of small
concentrations of cellular components carried in these extracellular microvesicles,
rich in biomarkers, among them proteins. Among the proteins found in urinary
exosomes are: Wilms-1 tumor protein (WT-1), which plays an important role in the
development of renal diseases; nephrin and podocin, key proteins in maintaining
the integrity of the glomerular filtration cleft.
Objective: Thus, this study aims to evaluate the WT-1, nephrin and podocin
proteins involved in slit diaphragm of the glomerular filtration from renal cortex and
exosomes urinary, which may represent potential early and non-invasive markers of
glomerular damage and of ND.
Materials and Methods: The animals were divided into 2 groups, diabetics induced
by Strepzotocin (STZ) and control, being evaluated in 2 periods (30 and 60 days),
regarding body weight and biochemical parameters such as glucose, urea, albumin
and creatinine.
Results: Reduction in body weight and serum albumin was observed in the diabetic
group when compared to the control group in both periods. There was also an
increase in serum glucose and urea concentrations in these same groups. In
addition, classic symptoms of T1DM, such as polyuria, polyphagia and polydipsia,
were observed.
Conclusion: Thus, the T1DM-induced by STZ was confirmed by hyperglycemia and
classic symptoms, such as body weight loss, polyuria, polyphagia, and polydipsia.
In addition, changes in concentrations of serum urea and albumin suggest a
possible initial renal damage in T1DM.

MEMBROS DA BANCA:
Presidente - 346847 - MARIA DAS GRACAS ALMEIDA
Externo ao Programa - 2477216 - NAISANDRA BEZERRA DA SILVA FARIAS
Interno - 1804884 - VIVIAN NOGUEIRA SILBIGER