Banca de QUALIFICAÇÃO: TAMIRES ROCHA FALCAO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : TAMIRES ROCHA FALCAO
DATA : 14/12/2016
HORA: 09:00
LOCAL: SALA DE AULA II DO PPGCF
TÍTULO:

Phytochemical characterization and evaluation of the cytotoxic, anti-microbiological, anti-inflammatory, antinociceptive activity of the crude extract and fractions of Eugenia uniflora L.

PALAVRAS-CHAVES:

Libidia ferrea, Eugenia uniflora, analgesic, anti-inflammatory.

PÁGINAS: 97
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

The species Libidia ferrea, popularly known as pau-ferro, is widely used in traditional
medicine as antibacterial, antiulcerogenic, anti-inflammatory and analgesic. Eugenia
uniflora L. belongs to the Family Myrtaceae, known a pitanga, popularly used in the
treatment of diarrhea, inflammation, hyperglycemia and hypertension. Medical health
considerations as a source of new drugs for the treatment of various pathologies, the
involvement of the inflammatory process in patients with severe diseases and the
symptoms of foot-and-mouth disease Preclinical aiming to evaluate an anti-inflammatory
and antinociceptive activity of extracts and brucellosis of Libidia ferrea and Eugenia
Uniflora L., by means of carrageenan induced peritonitis model, hot plate test and acetic
acid induced contortions in Swiss mice. From the dried and ground vegetable materials,
,were obtained by general methods of pharmacognosy crude extracts and fractions of
Eugenia uniflora L. (Aqueous crude extract, aqueous fraction, hexane fraction and ethyl
acetate fraction) and of Libidia ferrea (crude aqueous extract, crude extracts extracted with
ethanol 20, 40, 60 and 80%, fraction ethyl acetate and aqueous fraction). Chromatographic
analysis of the crude extracts and fractions allowed to separate and identify gallic acid,
retention time of about 8.7 minutes, and with elastic acid, with retention time of 25.1
minutes. Flavonoids were also detected, confirmed with the chromatographic data of the
standards. In the evaluation of leukocyte migration, the crude extract and the fractions of
Eugenia uniflora L. and Libidia ferrea at doses of 50, 100 and 200 mg / kg reduced the
number of inflammatory cells to the site of inflammation (p <0.001), comparing the groups
Treated with the positive control group. The decrease in the cellular influx was
accompanied by a decrease in myeloperoxidase activity, reduction of MDA, and showed
protection against a glutathione depletion (p <0.001). Administration of the crude extracts
and fractions produced a peripheral antinociceptive response at all doses tested, reducing
the significant number of contortions induced by acetic acid in mice, but showed little
significant central analgesic activity and was evaluated by the hot plate test. The results
indicate that these plants have anti-inflammatory and antinociceptive activities and support
their use in folk medicine.

MEMBROS DA BANCA:
Externo ao Programa - 2195251 - HUGO ALEXANDRE DE OLIVEIRA ROCHA
Presidente - 1544647 - MATHEUS DE FREITAS FERNANDES PEDROSA
Externo ao Programa - 2477216 - NAISANDRA BEZERRA DA SILVA FARIAS