Banca de DEFESA: RHADAMÉS MENEZES DA COSTA ROCHA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : RHADAMÉS MENEZES DA COSTA ROCHA
DATA : 31/07/2016
HORA: 15:00
LOCAL: SALA DE AULA II DO PPGCF
TÍTULO:

Characterization of γδ T cells in patients with cervical intraepithelial neoplasia (NIC)

PALAVRAS-CHAVES:

cervical intraepithelial neoplasia, Tγδ cells, flow cytometry.

PÁGINAS: 28
GRANDE ÁREA: Ciências da Saúde
ÁREA: Farmácia
RESUMO:

Invasive squamous cell carcinoma resulting from progression of precursor pre-invasive lesions known as cervical intraepithelial neoplasia (CIN) .In the United States (US), it is estimated that 12,990 new cases were diagnosed and 4,120 women are cervical cancer victims in 2016. Estimates from the National Cancer Institute (INCA) for the year 2016 in Brazil, indicate that cervical carcinoma being in 3rd place among 10 types of more incidents cancer, excluding non-melanoma skin. Evidence has implicated the Human Papillomavirus (HPV) as the primary etiologic agent of this câncer. The host immune system in most cases (80-90%) can eradicate the virus HPV, leaving only a smaller portion (10-20 %) of women who will present a persistent infection framework, may or may not progress to cervical cancer. The individual immune response is influenced by several endogenous and exogenous factors, among which: T cell profile, nutritional status, age, education, number of pregnancies, use of condoms, the first sexual intercourse, number of sexual partners over a lifetime , among others. Within this context is the Tγδ cells, a subpopulation of T cells, which already show significant activity studies. It is known that your presence in the tumor microenvironment may play a role in the progression or inhibition of tumor. The aim of our study is to quantify the percentage in the peripheral blood of Tγδ lymphocytes of patients with intraepithelial cervical neoplasms MEJC and correlate the groups of women with cervical cancer LEAGUE North Riograndense against cancer. The study was not observed that the comparison between the sociodemographic characteristics in groups of healthy women and cancer did not achieve a statistically significant difference. It is concluded that gamma delta T lymphocytes are in larger quantities in patients with cervical intraepithelial neoplasia grade 1 compared to the other groups. But follow-up studies are needed to understand the role of these cells to the progression of cervical cancers.

MEMBROS DA BANCA:
Presidente - 3313589 - JANAINA CRISTIANA DE OLIVEIRA CRISPIM FREITAS
Interno - 1804884 - VIVIAN NOGUEIRA SILBIGER