Banca de DEFESA: MARIA APARECIDA FELICIANO DE SOUZA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MARIA APARECIDA FELICIANO DE SOUZA
DATE: 16/10/2023
TIME: 14:00
LOCAL: Sala de Reuniões GEP/MEJC
TITLE:

Dual-stainig expression of p16/ Ki-67 in liquid-based cytology in cervical cancers: a scoping review.

KEY WORDS:

Cervical cancer; biomarkers; dual p16/Ki-67 staining; liquid cytology; screening.

PAGES: 51
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

This review aims to present an overview of p16/Ki-67 dual-staining (DS) expression in Liquid Based Cytology (LBC) in samples from patients with cervical cancer (CC). Material and Methods: This scoping review was developed following the guidelines for systematic reviews and meta-analyses for scoping reviews (PRISMA-ScR). A literature search using PubMed, Lilacs, Web of Science and Scopus electronic databases was conducted to identify studies that used DC for expression of p16/Ki-67 in CC in immunocytochemistry in LCB. The process of selecting and extracting data in a paired and independent way. The quality of included studies was assessed using the Joanna Briggs Institute Levels of Evidence. The review was registered in the Open Science Framework (OSF): DOI 10.17605/OSF.IO/9MUBQ. Results: Of the 149 studies analyzed, 7 studies, published between January 2018 and May 2023, were included in the qualitative synthesis. As expression parameters, p16/Ki-67 has been reported for DS in CBL in CC. Furthermore, we found that p16/Ki-67 in the CBL sample were expressed in squamous cell carcinoma (SCC). Conclusions: The study suggested that DC p16/Ki-67 is more frequently related to the CC group when compared to the HSIL and NILM group.

COMMITTEE MEMBERS:
Externa ao Programa - 2075402 - DEYSE DE SOUZA DANTAS - nullPresidente - 3313589 - JANAINA CRISTIANA DE OLIVEIRA CRISPIM FREITAS
Externo à Instituição - KLEYTON SANTOS DE MEDEIROS - LNRCC