Banca de DEFESA: ARTHUR NORONHA COSTA DO NASCIMENTO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ARTHUR NORONHA COSTA DO NASCIMENTO
DATE: 27/10/2022
TIME: 09:00
LOCAL: Sala de reunião da GEP, na Maternidade Escola Januário Cicco-UFRN / Videoconferência
TITLE:

PERINATAL TRANSMISSION OF CYTOMEGALOVIRUS IN PREMATURE NEWBORNS THROUGH BREAST MILK

 


KEY WORDS:

Cytomegalovirus; Breast Feeding; Infant, Premature; Intensive Care
Units, Neonatal.


PAGES: 90
BIG AREA: Ciências da Saúde
AREA: Medicina
SUBÁREA: Saúde Materno-Infantil
SUMMARY:

 

Human cytomegalovirus (CMV) is a double-stranded linear DNA virus and has a wide distribution worldwide, with its seroprevalence varying according to several epidemiological factors. Breastfeeding represents an important route of transmission of several infections from mother to child, including perinatal CMV infection. The present study is justified by the need for studies that address the incidence of cases of perinatal transmission and the correlation with risk factors and clinical outcome of premature neonates, contributing to the best decision to be made regarding breastfeeding, weighing the risks and benefits and, therefore, adopting the best medical conduct in Neonatal Intensive Care Units (NICU) regarding the safety of breast milk. The overall objective of this study was to evaluate the perinatal transmission of CMV in premature newborns (NB) from a NICU through breastfeeding. The study was observational, longitudinal cohort, prospective, involving premature newborns admitted to the NICU of the Januário Cicco Maternity School (MEJC) during the period from September 30, 2021 to June 2, 2022 with gestational age less than 33 weeks or birth weight less than 1500g, excluding cases of severe birth defects. All mothers underwent postpartum blood draws and were tested for CMV seropositivity. The biological samples of preterm infants' urine and breast milk were submitted to molecular biology techniques (extraction, PCR, and electrophoresis). Clinical and laboratory data were obtained from medical records obtained by the Neonatology team of the maternity ward. Partial results showed seropositivity for IgG anti-CMV antibodies in 76/77 mothers (98.70%) and IgM in 3/77 patients (3.90%). The rate of virus detection in breast milk was analyzed in 21/63 (33%) mothers with available milk samples. The incidence of perinatal infection via breast milk was analyzed in 3/45 (6.66%) RNs with available urine samples. It was not possible to associate perinatal infection with clinical symptoms and risk factors for disease development due to the limited incidence of perinatal infection cases.


COMMITTEE MEMBERS:
Externa à Instituição - NAYARA GONÇALVES BARBOSA - UFJF
Externo à Instituição - KLEBER JUVENAL SILVA FARIAS
Presidente - 1801992 - PAULA RENATA LIMA MACHADO
Notícia cadastrada em: 06/10/2022 10:30
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