Banca de QUALIFICAÇÃO: ARTHUR NORONHA COSTA DO NASCIMENTO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ARTHUR NORONHA COSTA DO NASCIMENTO
DATE: 05/08/2022
TIME: 15:00
LOCAL: Videoconferência
TITLE:

PERINATAL TRANSMISSION OF CYTOMEGALOVIRUS IN PREMATURE
NEWBORNS THROUGH BREAST MILK

KEY WORDS:

Cytomegalovirus; Breast Feeding; Infant, Premature; Intensive Care
Units, Neonatal.

PAGES: 53
BIG AREA: Ciências da Saúde
AREA: Medicina
SUBÁREA: Saúde Materno-Infantil
SUMMARY:

 

Human cytomegalovirus (CMV) is a double-stranded linear DNA virus and has a wide distribution worldwide, with its seroprevalence varying according to several epidemiological factors. Moreover, it is a common cause of maternal-fetal infection that can lead to severe short- and long-term sequelae in premature and low-birth-weight infants. Breastfeeding represents an important route of transmission of several infections from mother to child, including perinatal CMV infection. The present study is justified by the need for studies that address the incidence of cases of perinatal transmission and the correlation with risk factors and clinical outcome of premature neonates, contributing to the best decision to be made regarding breastfeeding, weighing the risks and benefits and, consequently, adopting the best medical conduct in NICUs regarding the safety of breast milk. The overall objective of this study was to evaluate the perinatal transmission of CMV in premature newborns from a NICU through breastfeeding. The study was observational, longitudinal cohort, prospective, involving premature newborns admitted to the Neonatology Intensive Care Unit (NICU) of the Januário Cicco Maternity School (MEJC) during the period from September 30, 2021 to June 2, 2022 with gestational age less than 33 weeks or birth weight less than 1500g, excluding cases of severe malformations at birth. All mothers underwent postpartum blood draws and were tested for CMV seropositivity. The biological samples of preterm infants' urine and breast milk were submitted to molecular biology techniques (extraction, PCR, and electrophoresis). Clinical and laboratory data were obtained from medical records obtained by the Neonatology team of the maternity. Partial results showed seropositivity for IgG anti-CMV antibodies in 76/77 mothers (98.70%) and IgM in 3/77 patients (3.89%). The rate of virus detection in breast milk was analyzed in 21/63 (33%) mothers with available milk samples. The incidence of congenital infection was analyzed in 2/76 RNs with available urine samples (2.63%). The incidence of perinatal infection via breast milk was analyzed in 3/48 RNs with available urine samples (6.25%). In only one case, 1/76 RNs (1.31%), the result of perinatal transmission was inconclusive. We also hope to correlate the results of the incidence of perinatal transmission via breast milk with risk factors and clinical outcome in order to evaluate and define the real safety of breast milk for premature infants in the NICU of the maternity hospital.

COMMITTEE MEMBERS:
Externo à Instituição - KLEBER JUVENAL SILVA FARIAS - UFCG
Presidente - 1801992 - PAULA RENATA LIMA MACHADO
Externa ao Programa - 350753 - VALERIA SORAYA DE FARIAS SALES - null