Banca de DEFESA: NAYARA SOUSA DA SILVA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : NAYARA SOUSA DA SILVA
DATE: 17/11/2023
TIME: 14:00
LOCAL: Online (link: https://meet.google.com/teq-ubgt-nts)
TITLE:

Clinical Characteristics Associated with COVID-19 Severity and Predisposition to Post-COVID Condition Development

KEY WORDS:

Long COVID, Public Health, COVID-19 Drug Therapy.

PAGES: 79
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Brazil has recorded approximately 37 million cases of COVID-19 as of January 2023. Besides the acute manifestations, COVID-19 might progress to a chronic disease, known as Post-COVID Condition (PCC). Longitudinal studies are essential for comprehending the long-term impacts of COVID-19. This study describes the clinical profile of a cohort of 704 patients infected with SARS- CoV-2 in 2020 and examines the health consequences and quality of life two years after infection. The first stage of the study characterized the acute phase of COVID-19 in patients infected in 2020. Critical cases accounted for 29% of the studied group, with male sex and the presence of diabetes posing higher risks for disease severity (RR=1.76; 95%CI: 1.43 – 2.17 and RR=1.60; 95%CI: 1.28 – 2.00). The use of "COVID Kit" medications—antimalarials, azithromycin, and ivermectin—was significantly higher in severe and critical severity groups (p=0.010, p<0.001, p=0.010, respectively), but no impact on patient survival was observed. A total of 105 patients died due to COVID-19 and its complications. The second stage of the study took place between May and June 2022, involving 137 individuals with the goal of investigating PCC. Persistent symptoms were reported by 56.9% of patients. Women and individuals hospitalized during the acute infection phase faced a higher risk of experiencing symptoms after COVID-19 (RR=2.07; 95%CI: 1.47 – 2.94 and RR=1.53; 95%CI: 1.07 – 2.18). Respiratory disturbances, neurological effects, and body pains were the most frequently reported manifestations. At least 20% of individuals reported some degree of difficulty in performing daily activities. Finally, countries that have encountered high rates of SARS-CoV-2 infection must be prepared to address the long-term consequences of COVID-19. In this context, our study is pivotal in providing an overview of the Brazilian situation and guiding further research as well as the formulation of targeted public policies for addressing PCC.

COMMITTEE MEMBERS:
Presidente - 2087759 - ANDRE DUCATI LUCHESSI
Interno - 1545315 - GUILHERME AUGUSTO DE FREITAS FREGONEZI
Externo à Instituição - OTAVIO CABRAL MARQUES - USP
Externo à Instituição - PEDRO BRAGA NETO - UFC
Externo à Instituição - RICARDO NEY OLIVEIRA COBUCCI - UnP