Banca de DEFESA: JANAINA FERREIRA ADERALDO

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : JANAINA FERREIRA ADERALDO
DATE: 29/07/2022
TIME: 14:00
LOCAL: Online (Google Meet)
TITLE:

A DEFINIR

KEY WORDS:

Infertility; assisted human reproduction; market; global market; add-ons; microfluidics for sperm selection; MFSS; seminal microbiome; WGS; spermogram; seminal quality.

PAGES: 91
BIG AREA: Ciências Biológicas
AREA: Genética
SUMMARY:

Infertility is defined as failure to obtain a pregnancy after 12 months of regular unprotected sexual intercourse or as conditions incompatible with the meeting of gametes. Virtually all regions have experienced fertility declines in recent decades, to the point of being included in the United Nations Millennium Development Goals, which includes infertility as a global health problem. In this context, the size of the global assisted reproductive technology (ART) market was around USD 26 billion in 2019 and is expected to reach USD 45 billion by 2025. We have carried out a scoping review as a starting point for understanding the global market scenario in assisted human reproduction (AHR). To this end, we use topic modeling, an automated tool used to detect textual patterns. In this way, we identified the most covered topics in peer-reviewed texts and gray literature related to the market in AHR. We present these topics in a structured and commented way, having as main findings: a) despite the AHR market-moving billions of dollars worldwide and having expectations of growth in supply and demand in all scenarios studied, despite technological advances and insertion of technologies accessories (add-ons) over the last decades, the global success rates in RHA remain around 30% of the cycles performed; and b) the number of texts on these health technologies assessment (HTA) was insignificant, despite moving about USD 13.75 billion in 2020 and lacking significant evidence on success rates in AHR. Of the afore mentioned technologies, the use of microfluidics for sperm selection (MFSS) is in vogue. We performed the first meta-analysis to identify the potential benefits of using this device on clinical pregnancy and abortion rates in assisted reproduction treatments (ART). The results indicate a slight increase in the clinical pregnancy rate and a decrease in abortion rates about the sperm selection techniques by density gradient and swim-up; however, these results did not show statistical significance. Thus, the most robust indicators of success in ART remain maternal age, ovarian reserve, and qualitative and quantitative sperm analysis. Researchers have been dedicated to the search for immunogenic factors that contribute to the elucidation of the key factors responsible for infertility, especially in cases with no apparent cause. For this reason, we are dedicated to the first worldwide study on the application of metagenomic prospecting in seminal samples, whose choice of technique is justified by the possibility of non-directed identification of organisms. We used a pool of seminal samples provided by volunteers at the Reproductive Rights Unit at Maternity School Januário Cicco (MEJC). We found 71.3% bacterial domain, 27.6% eukaryotic domain, and 1.1% viral community. These findings expand the current view on the functional microbiota and point to future investigations as to the role of non- culturable microorganisms in the reproductive system. In addition, the Herv families identified in seminal samples deserve studies with a functional and evolutionary perspective. These data contribute to a new research front in the diagnosis of fertility- related diseases.

COMMITTEE MEMBERS:
Externo à Instituição - ARLINDO ALENCAR DE ARARIPE MOURA - UFCA
Presidente - 1880243 - DANIEL CARLOS FERREIRA LANZA
Externa ao Programa - 1718086 - DANIELLE BARBOSA MORAIS - nullExterno à Instituição - MAURICIO FRAGA VAN TILBURG - FIOCRUZ
Externo ao Programa - ***.283.220-** - RICARDO NEY OLIVEIRA COBUCCI - EBSERH