Introduction: The subject of patient safety has been discussed among service providers, health institutions and governments in its different spheres, for more than a decade. In this sense, the number of research is increasing, demonstrating that the patient's participation in their care is fundamental to avoid adverse events. Risk management not only by the team, but also by the patient and their companion, brings transparency and shared responsibility in the health decision-making process. Still, in clinical practice, there is a need for change in the health context about empowering the patient, who is the actor who should be directly involved in their care. Person-centered care, therefore, makes the patient a partner of the care team, which can act as a barrier to adverse events. Considering a situational diagnosis carried out in 2019 at the hospital in the period between 2015 and 2018, in which the referred study was carried out, a total of 749 adverse events were recorded, of which one died, called Never events, an event that was not supposed to happen ( VIGIHOSP, 2016). Aims: a) to identify, through a systematic review of the literature, the impact of patient empowerment in reducing adverse events during hospitalization; b) get to know the perception of HUGV / AM professionals about the patient's empowerment in the prevention of adverse events; c) analyze the effect of an intervention in the team's routine in reducing adverse events; d) produce educational material that must be transmitted via AVASUS. Method: mixed method research consisting of a) a systematic literature review study for which a specific protocol was used based on the PRISMA-P checklist, based on the acronym PICO, following the checklist criteria. The search strategies were applied in the databases (Cochrane, Lilacs, PubMed, Scopus, and Web of Science) and in the gray literature (Google scholar, Open Gray, and ProQuest). The risk of bias was assessed using the Cochrane Critical Assessment Checklist for intervention studies and the quality of evidence was assessed by GRADE; b) a cross-sectional, exploratory-analytical case study; c) medium-term, applied research using light technology. The professionals who worked in the care of adult patients admitted to the medical clinic of HGV / AM participated in studies b and c. d) methodological research for the development of a script for educational material. Quantitative descriptive, inferential, and qualitative analyzes were performed on the data obtained in the studies. Results: a) Returned, after applying the inclusion / exclusion criteria 6 articles for systematic analysis; b) professionals perceive that patient empowerment is important for the prevention of adverse events; c) during the period of 1 year, observing the insertion of questions about the patient's empowerment in the face of adverse events in the professionals' routine form, there was a statistically significant difference in the reduction of adverse identification events and falls, but not in the events of skin damage and medication administration; d) after revising the script, it is approved and will be used for the production of educational material via AVASUS, as part of the Patient Safety Course already on the platform. Conclusion: The empowerment of the patient and his companion can reduce adverse effects during hospitalization and the proposition of interventions with light technology, as the insertion of questions in the patient safety form represents a low cost possibility for minimizing AE in hospitals. Longitudinal studies with the adoption of other interventions to raise awareness among health teams, patients, and their companions about their role in preventing adverse events are desirable.