Dengue is a disease associated to many adverse effects on the Brazilian economy, represented not only by health care expenditures, but also by the loss of productivity of the workers and by the decrease in tourism revenues. In addition, in recent years it has been discovered that Aedes aegypti is also a vector for chikungunya and Zika, diseases that leave severe sequels in the infected person, with the last one associated to a generation of babies affected by a severe form of microcephaly. Because of the persistence of the problem, some municipalities have adopted innovative biological control strategies. Among them is the release of the genetically modified mosquito (called OX513A), a lineage of male mosquitoes developed by the company Oxitec, which has already been implemented in the municipalities of Juazeiro/BA, Jacobina/BA, Piracicaba/SP, Juiz de Fora/MG and Indaiatuba/SP. In the present study, we will evaluate the impact of this strategy on the incidence of dengue, through the synthetic control method, which allows the construction of a counterfactual for the treated municipalities through the optimal weighting of municipalities that did not adopt the strategy. The results showed that the effects are not statistically significant, and so can not be meaningfully interpreted.