Banca de DEFESA: VICTOR HUGO BRITO DE OLIVEIRA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : VICTOR HUGO BRITO DE OLIVEIRA
DATE: 07/08/2020
TIME: 09:00
LOCAL: VIDEOCONFERÊNCIA
TITLE:

Cystic fibrosis: an analysis carried out under different aspects


KEY WORDS:

Keywords: Cystic fibrosis, adverse effects, posture, breathing exercises

Keywords: social stigma, cystic fibrosis, validation.


PAGES: 40
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:
Abstract Estudo 1 Introduction: Cystic fibrosis is a multisystem disease, but with pulmonary
involvement as the main cause of death. Objective: To investigate the repercussions of home
inspiratory muscle training on posture, quality of life and the possible adverse effects reported by
individuals with cystic fibrosis. Materials and methods: In a double-blind randomized controlled clinical
trial (NCT03737630), patients of both sexes with a diagnosis of cystic fibrosis confirmed by the
sweat test underwent pulmonary function test, respiratory muscle strength, postural assessment,
quality of life and 3-minute step test. After that, they were divided into two groups (G40% and G20%).
For the training protocol, everyone received a POWERBREATHE © and the G40% group trained with 40%
of the MIP load, with load progression every week and the G20% with 20% of the MIP load without load
progression for 4 weeks, 2x a day, 30 breaths. After four weeks, the individuals were reevaluated.
The data were analyzed using SPSS 20.0, with a 5% significance level. The Shapiro-Wilk test was used
and, according to the data distribution, the unpaired t ’test was used to compare the means between
the groups. Results: Ten patients (6 men and 4 women) with a mean age of 19 ± 3.2 years were
evaluated. There was a significant reduction of 6.8 cm in the T1 / T2 angle of postural assessment with
a 95% confidence interval: 8.2 (0.01 - 16.3) and clinical FVC gains for both groups and FEV1 for the
group G20%, considering the respective minimally important clinical differences (MCID). No major
adverse effects have been reported. The other variables did not present clinical and / or significant
changes. Conclusion: The protocol proposed by this study was not sufficient to generate positive
effects on all variables, however due to the absence of adverse effects, it can be considered safe to
be performed at home.


Abstract estudo 2 Introduction: The experience of stigma is present in all stages of an individual's
life with cystic fibrosis, requiring the availability of instruments to assess this psychosocial aspect.
However, there are few of these instruments validated and adapted to the Portuguese language.
Objective: Translate, make the cross-cultural adaptation and evaluate the psychometric properties
of the Cystic Fibrosis (CF) stigma scale. Materials and methods: Exploratory methodological study
that involved the process of translation and crosscultural adaptation through translation,
back-translation, revision by a multiprofessional committee composed of 10 specialists and 30
individuals with cystic fibrosis in the pre-test phase. Subsequently, the psychometric properties
were analyzed through the application of the adapted instrument in a sample of 52 Brazilian
individuals over 18 years old and with cystic fibrosis. A stigma assessment was carried out using
the CF stigma scale adapted to Portuguese, generic quality of life by The Short Form 12v2, anxiety
by The Generalized Anxiety Disorder Questionnaire and specific quality of life for cystic fibrosis by
the quality of life questionnaire in cystic fibrosis and a reevaluation 3 weeks later. The data were
analyzed using the SPSS26.0 software, with a significance level of 5%. The normality of the data
 was verified by the Kolmogorov-smirnov test. Two types of reliability were considered in the total
 score and in the subscales: internal consistency using Cronbach's alpha and test-retest reliability
 using paired t-test and Pearson's correlation. Results: The process of translation and cross-cultural
 adaptation obtained kappa indexes higher than 0.61 in the multiprofessional committee phase and
 varied between 0.48 and 0.72 in the pre-test. The Brazilian version of the CF Stigma Scale showed
 excellent psychometric properties: 1) Internal consistency: α = 0.836 2) Test-retest: r = 0.886,
p <0.0001 3) Convergent validity of p = 0.3. The CF Stigma Scale score correlated positively with
 the anxiety scale (r = 0.384, p = 0.005) and negatively with the scores for general quality of life
 (r = -0.430, p = 0.001) and specific for cystic fibrosis (r = -0.484, p <0.001). Conclusion: The CF
 Stigma Scale questionnaire was properly translated and adapted to the Brazilian reality, which has
 good psychometric properties and can be used in the Brazilian territory for future studies involving
 the experience of stigma in patients with cystic fibrosis.







BANKING MEMBERS:
Externa à Instituição - GARDENIA MARIA HOLANDA FERREIRA - NENHUMA
Externo ao Programa - 1754525 - IVAN DANIEL BEZERRA NOGUEIRA
Externa à Instituição - IVANIZIA SOARES DA SILVA - UFRN
Externo ao Programa - 1323908 - JOAO CARLOS ALCHIERI
Presidente - 1632408 - PATRICIA ANGELICA DE MIRANDA SILVA NOGUEIRA
Notícia cadastrada em: 28/07/2020 09:01
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