Banca de DEFESA: RITA YANKA PEREIRA DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : RITA YANKA PEREIRA DA SILVA
DATE: 21/12/2022
TIME: 14:30
LOCAL: Link de acesso para videoconferência: meet.google.com/pii-hihv-pgr
TITLE:

Microparticles in the development and improvement of pharmaceutical formulations: an analysis of in vitro and in vivo studies


KEY WORDS:
Triterpenes, α-amyrin, β-amyrin, polymeric microparticles, LXR, alpha-glucosidase.

PAGES: 87
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
Triterpenoids have aroused the interest of the scientific community in recent
years due to the use, in popular medicine, of natural complexes that contain these
substances in their composition. Among them, there is α, β-amyrin, a pentacyclic
triterpene that consists of an isomeric mixture of compounds with ursane and
oleonane backbone. Some pharmacological activities have been reported,
however, without a defined target. In addition, the low solubility in water hinders
the absorption of the compound. In this work, polymeric microparticles with
HPMC were developed to carry α, β-amyrin and the biological activity against α-
glucosidase, pancreatic lipase, LXRβ and antioxidant was investigated. In
addition, the physical-chemical characterization of the obtained systems was
carried out. In it, the FTIR showed effective interaction between the active
principle and the polymer; in the DR-X, it was observed that the isolated active
presents high crystallinity, but, when incorporated into polymeric microparticles,
this crystallinity decreased; SEM, as well as DR-X, showed α, β-amyrin as a
highly crystalline structure, with well-defined, long, needle-shaped crystals. When
inserted into the microparticles, the crystals, although still visible, were
considerably reduced in size. In biological activity assays, the systems did not
show activity against pancreatic lipase. Hypolipidemic and hypoglycemic
activities have already been described for α, β-amyrin, but without a defined
biological target, therefore, biological activity assays sought to test some targets
in an attempt to define whether they were responsible for these activities. The
results of the test against lipase and α-glucosidase were not satisfactory,
however, the agonist activity of the nuclear receptor LXRβ showed that the active
product produces agonist activity on this receptor. More studies seeking to
elucidate the targets through which α, β-amyrin exerts its effects must be carried
out and other studies delving into its effect on the LXRβ receptor.

COMMITTEE MEMBERS:
Presidente - 1789788 - ADLEY ANTONINI NEVES DE LIMA
Interno - 3652554 - FRANCISCO CANINDE DE SOUSA JUNIOR
Externo à Instituição - JOSÉ OTÁVIO CARRÉRA SILVA JÚNIOR - UFPA
Notícia cadastrada em: 06/12/2022 17:53
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