Banca de DEFESA: GRAZYELE MEDEIROS DINIZ

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : GRAZYELE MEDEIROS DINIZ
DATE: 18/12/2023
TIME: 07:30
LOCAL: MODO REMOTO
TITLE:

FORMATION AND CHARACTERIZATION OF ORGANOGELS FOR VITAMIN E DELIVERY

KEY WORDS:
PAGES: 102
BIG AREA: Engenharias
AREA: Engenharia Química
SUMMARY:

Topic drug administration is a non-invasive, easy and advantageous route for the absorption of an active ingredient in the body. As well as in the pharmaceutical area, the cosmetics industry uses this material transfer mechanism in order to prevent degradation caused by interactions with other compounds before absorption through the skin. Among the variety of bioactive delivery systems, organogels have stood out as materials with an interesting structure for the controlled release of bioactive compounds. These materials are semi-solids formed by the mixing of small concentrations of gelator (<15%) and organic solvent. In parallel, an active compound of interest in these areas is vitamin E, an important fat-soluble nutrient, which has antioxidant, humectant and emollient properties, to name a few. In this context, this study aims to prepare and characterize organogels for the delivery of vitamin E for applications in the cosmetics and pharmaceutical industry. Coconut oil (OCO), canola oil (OCA) and oleic acid (AO) were investigated as organic solvents, whereas Tween 80 (T80) and PEG 300 (P300) were investigated as gelators. Firstly, the phase behavior of the systems was studied, and the pseudo-ternary diagrams were constructed. Next, vitamin E was incorporated into the gels, and these systems were characterized through Zeta potential and pH analyses, and the stability and potencial for vitamin E delivery through the gels were evaluated. Finally, the possibility of quantifying vitamin E in the formulations was assessed using the UV spectrophotometry technique.  Solubility tests of the P300-OCO binary mixture indicated a lack of affinity between this structuring agent and the organic solvent. Consequently, PEG-300 was excluded from further investigation. Tween 80 successfully structured the organic solvents in all three studied systems (OCO/T80/water, OCA/T80/water, AO/T80/water), and the gels obtained with the lowest concentration of structuring agent in each system were characterized. Lastly, UV spectrophotometry was not suitable for quantifying the vitamin E incorporated in the gels due to interference caused by the excipients in the absorption of UV radiation at the same wavelength as vitamin E.

COMMITTEE MEMBERS:
Externo à Instituição - ADOLFO LOPES DE FIGUEREDO - USP
Presidente - 1543286 - CAMILA GAMBINI PEREIRA COURTIAL
Externa ao Programa - 1415919 - KATHERINE CARRILHO DE OLIVEIRA DEUS - nullExterna à Instituição - SUZARA RAYANNE DE CASTRO SENA - UFRN