The presence of monoethylene glycol (MEG) can cause  precipitation of salts present in the produced water, generating undesirable incrustations in the pipes and devices of the operations of petroleum and natural gas processing. The most common salt incrustations is calcium carbonate (CaCO₃), due to its low solubility in water, and abundance of carbon dioxide (CO₂) in the reservoirs . Sodium chloride (NaCl) is also widely found in incrustations, and directly influences the solubility of calcium carbonate. This work aims to study the behavior of calcium carbonate solubility in aqueous solutions containing sodium chloride, monoethylene glycol, and carbon dioxide. For this, a study was carried out to define an approach for calculating the solubility of calcium carbonate in water, which was compared to literature data. Then, data analysis was performed from the H₂O+CaCO₃+CO₂ system at 278.15 K, 283.15 K, and 298.15 K, and the H₂O+CaCO₃+CO₂+MEG system at 298.15 K, both varying the pressure of CO₂, and the concentration of monoethylene glycol. These solubility measurementswere obtained by the analytical method using equilibrium cells. Experiments were also performed to determine solubility data in the modified Othmer ebulliometer for the H₂O+NaCl, H₂O+CO_2, and H₂O+CaCO₃+CO₂ systems. For the first system, tests were carried out at different pressures and concentrations until salt saturation. For the second system, the test was performed at a pressure close to atmospheric with a constant partial pressure of CO₂. Finally, for the third system, the test was also performed at a pressure close to atmospheric, in the condition of carbonate saturation and with a constant partial pressure of CO₂. The defined modeling demonstrated agreement with literature data, requiring the application of a mean ionic activity coefficient for a better description. Regarding the solubility data obtained in the glass equilibrium cells, they agree with the literature and with the expected behavior for the systems studied. The equilibrium measurements of the H₂O+NaCl system showed agreement with the literature up to the salt saturation. In addition, it was possible to identify that the temperature values collected from the liquid best represented the phase equilibria. Finally, the equilibrium data of the H₂O+CO₂ and H₂O+CaCO₃+CO₂ systems showed that CO₂ dissolves better in the vapor phase, due to the condensate having a lower temperature compared to the boiler. For the system in the saturation condition of CaCO₃, solubilities of 58.60 ppm and 71.50 ppm were obtained, respectively for ebulliometers 1 and 2 for the test without carbonated water, and an average solubility of 55.55 ppm for the tests with carbonated water, showing coherence, as they are in the same order of magnitude of values in the literature. The equilibrium data determined in this work aims to improve the processes present in oil and gas production, allowing the parametrization of models that will be useful to simulate the operations of interest in conditions in which experimental data is not available.