Banca de QUALIFICAÇÃO: GRAZYELE MEDEIROS DINIZ

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : GRAZYELE MEDEIROS DINIZ
DATE: 02/09/2020
TIME: 09:00
LOCAL: VIRTUAL
TITLE:

FORMATION AND CHARACTERIZATION OF ORGANOGELS FOR VITAMIN E DELIVERY

KEY WORDS:
PAGES: 27
BIG AREA: Engenharias
AREA: Engenharia Química
SUMMARY:

Topic drug administration is a non-invasive, easy and advantageous route for the absorption of an active ingredient in the body. As well as in the pharmaceutical area, the cosmetics industry uses this material transfer mechanism in order to prevent degradation caused by interactions with other compounds before absorption through the skin. Among the variety of bioactive delivery systems, organogels have stood out as materials with an interesting structure for the controlled release of bioactive compounds. These materials are semi-solids formed by the mixing of small concentrations of gelator (<15%) and organic solvent. In parallel, an active compound of interest in these areas is vitamin E, an important fat-soluble nutrient, which has antioxidant, humectant and emollient properties, to name a few. In this context, this study aims to prepare and characterize organogels for the delivery of vitamin E for applications in the cosmetics and pharmaceutical industry. Tween 80 and PEG 250 will be investigated as gelators, whereas coconut oil, canola oil and oleic acid will be investigated as organic solvents, and isopropyl acid will be used as a cosurfactant. First, the phase behavior of the systems will be studied, and the pseudo-ternary diagrams will be constructed. Then, vitamin E will be incorporated into the gels and they will be characterized through surface tension, rheology, Zeta potential and scanning electron microscopy (SEM) analysis. Finally, the stability and possibility of delivery of vitamin E through the gels will be assessed.

BANKING MEMBERS:
Presidente - 1543286 - CAMILA GAMBINI PEREIRA
Externa ao Programa - 1415919 - KATHERINE CARRILHO DE OLIVEIRA
Externa à Instituição - SUZARA RAYANNE DE CASTRO SENA - UFRN